Plinest polynucleotides are a revolutionary bioregenerative aesthetic treatment designed to rejuvenate the skin by stimulating natural collagen production, enhancing hydration, and improving tissue repair. Derived from purified salmon DNA, Plinest works at a cellular level to restore elasticity, reduce wrinkles, and improve overall skin texture.

This innovative injectable treatment is gaining popularity for skin rejuvenation, scar healing, and anti-aging benefits, offering a non-surgical approach to improving skin quality and radiance. If you’re considering a natural yet effective way to enhance your skin, Plinest polynucleotides could be the perfect solution.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, the essential building blocks of DNA and RNA. In aesthetic medicine, polynucleotides derived from salmon DNA have been found to stimulate fibroblasts, promoting collagen and elastin production, which are crucial for maintaining firm, youthful skin.

Unlike traditional dermal fillers, which focus on adding volume, polynucleotides focus on improving skin health from within. They work by:

• Enhancing tissue regeneration

• Boosting hydration and elasticity

• Reducing inflammation and oxidative stress

• Improving skin texture and tone

This makes them an ideal treatment for aging skin, acne scars, and overall skin quality enhancement.

What Is Plinest?

Plinest is a next-generation polynucleotide treatment developed by Mastelli, an Italian leader in regenerative medicine and distributed by Dermafocus. Unlike other polynucleotide-based injectables, Plinest uses the Mastelli PN-HPT® (Polynucleotide High Purification Technology), ensuring a higher degree of purification and superior biocompatibility.

Plinest is specifically designed for:

• Revitalizing aging skin

• Reducing fine lines and wrinkles

• Enhancing skin hydration and firmness

• Improving scars, stretch marks, and post-surgical healing

• Boosting skin elasticity and collagen production

This treatment is particularly effective for delicate areas like the face, neck, décolletage, and hands, where skin tends to lose volume and elasticity over time.

How Does Plinest Work?

Plinest works by triggering the body’s natural repair processes through biostimulation. The purified polynucleotides injected into the skin act as a scaffold for fibroblast activation, leading to:

1. Collagen and Elastin Stimulation – Plinest promotes the synthesis of these structural proteins, improving skin firmness and elasticity.

2. Deep Hydration – The treatment increases water retention, giving the skin a plumper, dewy appearance.

3. Anti-Inflammatory Effects – Polynucleotides help combat oxidative stress and free radicals, reducing inflammation and protecting the skin from premature aging.

4. Tissue Regeneration – Plinest enhances cell turnover and wound healing, making it an excellent treatment for scars, stretch marks, and post-procedural skin recovery.

Benefits of Plinest Polynucleotides

1. Natural Skin Rejuvenation

Unlike synthetic fillers, Plinest works with your body’s natural processes, ensuring a subtle, natural enhancement without over-volumization.

2. Deep Hydration

Polynucleotides increase the skin’s ability to retain moisture, making it particularly beneficial for dry, dehydrated, or mature skin.

3. Anti-Aging Properties

By stimulating collagen and elastin production, Plinest helps smooth fine lines and wrinkles, restoring a youthful glow.

4. Scar and Stretch Mark Improvement

Plinest is widely used for treating acne scars, surgical scars, and stretch marks, improving overall skin texture and tone.

5. Minimal Downtime

Plinest treatments involve quick, non-invasive injections with little to no downtime, making it an ideal lunchtime procedure.

Who Is Plinest Polynucleotide Treatment For?

Plinest is suitable for individuals who want to:

• Improve skin texture, elasticity, and hydration

• Reduce fine lines, wrinkles, and sagging

• Boost collagen production and tissue regeneration

• Enhance scar healing and reduce post-acne marks

• Achieve natural-looking, long-term skin rejuvenation

It is particularly beneficial for those experiencing:

• Aging skin with reduced elasticity

• Dry, dehydrated, or dull skin

• Scarring from acne, surgery, or injuries

• Dark circles and under-eye hollowness

• Sun-damaged skin

Plinest vs. Other Polynucleotide Treatments

Feature	Plinest	Nucleofill	Rejuran (PN/PDRN)
Source	Mastelli’s patented PN-HPT® (High Purification Polynucleotides)	Non-crosslinked polynucleotides	Polynucleotide from salmon DNA
Hydration	High	Moderate	High
Skin Firming	Excellent	Best for lifting	Good
Scarring Benefits	Superior	Moderate	Good
Downtime	Minimal	Minimal	Minimal

Plinest stands out due to its proven clinical research, superior purification process, and its ability to deliver deep tissue biostimulation with long-lasting results.

What Areas Can Be Treated with Plinest?

• Face – Enhances skin quality, reduces wrinkles, and boosts hydration.

• Neck & Décolletage – Firms sagging skin and improves texture.

• Hands – Restores youthful volume and hydration.

• Scars & Stretch Marks – Accelerates healing and smooths skin irregularities.

• Under-Eyes – Reduces dark circles and fine lines.

How Many Sessions Are Required?

Most patients require 3-4 sessions spaced 2-4 weeks apart for optimal collagen stimulation and skin regeneration. Maintenance treatments every 6-12 months help prolong the results.

Plinest Polynucleotide Results: Before & After

• Week 1: Improved hydration and skin plumpness.

• Week 4-6: Noticeable reduction in wrinkles and fine lines.

• Week 12: Maximum collagen regeneration, leading to firmer, more youthful skin.

Results continue to improve over time, making it a long-term solution for skin rejuvenation.

This patient underwent polynucleotide treatment with Dr Negar Sharafi

Plinest Polynucleotides vs. Traditional Fillers

Aspect	Plinest Polynucleotides	Hyaluronic Acid Fillers
Purpose	Biostimulation & skin regeneration	Volume restoration
Longevity	6-12 months	6-18 months
Hydration	Deep, long-lasting hydration	Temporary hydration
Collagen Stimulation	Yes	Minimal
Downtime	Low	Low

Unlike fillers, Plinest enhances skin health over time rather than just adding volume.

Plinest Polynucleotide Cost in the UK

The cost of Plinest treatments varies based on the clinic, practitioner expertise, and the number of sessions required. At CLNQ, a single session costs £300.

Conclusion: Is Plinest the Right Choice for You?

Plinest polynucleotides offer a natural, science-backed approach to skin regeneration, anti-aging, and tissue repair. Whether you’re looking to boost collagen, reduce wrinkles, or improve skin texture, this treatment provides long-lasting benefits with minimal downtime.

If you want to experience firmer, more radiant skin with a natural glow, Plinest could be your ideal aesthetic solution. At CLNQ, we offer expert-led Plinest polynucleotide treatments tailored to your unique skin needs. Book your consultation today to using our online booking system here.